The conflict and resulting devastation make the advanced Krogan society devolve into a collection of warring clans fighting over a wasteland.ДЎ600 BCE - A mysterious alien species called the Jardaan create a new species called the Angara and spread it across multiple worlds in the Heleus Cluster of the Andromeda galaxy.ДҐ80 BCE - The Asari develop faster-than-light spacefaring by studying leftover Prothean technology, and become the first civilization since the Protheans to discover the Citadel space station.ДҐ20 BCE - The Salarians discover the Citadel and open diplomatic relations with the Asari.ДҐ00 BCE - The Citadel Council is formed. Before they're wiped out, the Protheans stop all study of primitive species, in the hope that the Reapers would see them as too primitive and leave them alone.ДЎ3,000 BCE - The Turians begin to develop civilization on the planet Palaven.ДЎ900 BCE - The Krogans enter the nuclear age, which results in a global conflict that decimates the planet and triggers an eternal nuclear winter. The result is the subservient species called the Collectors. Some captured Protheans are subjected to extensive experimentation, implanted with cybernetics and have their genes altered by the Reapers. Having united the empire under the Prothean culture, the Reapers easily toppled the ruling body first, causing the rest of the empire to slowly crumble over the next couple of centuries, where the Protheans are methodically wiped out. The Protheans observed primitive species like humans, and placed outposts near the creatures' homeworlds to monitor them.Д¤8,000 BCE - Though they knew of the Reapers' existence and had begun preparations to fend off against them, the Protheans are caught off-guard by the massive army of Reapers that arrive to the Milky Way through the Citadel. To fight it off, the Protheans decide to unite all sentient organic life in the galaxy under their empire, assimilating them into Prothean culture.

At some point, the Protheans encounter a hostile synthetic intelligence that threatens their existence. They begin spreading out across the galaxy, using the colossal deep-space station dubbed the Citadel as their capital. Each new species joining the party makes up a new Reaper ship, all made in the image of the Leviathans.Д¦8,000 BCE - The Prothean civilization achieves spaceflight and discovers the mass relay network from the ruins of an extinct civilization. The Leviathans become extinct, and an eons-long cyclical harvest of the intelligent organic life in the galaxy by the Reapers every 50,000 years begins. Right before going to rest on the 7th day, The Catalyst builds a network of mass relays, which would allow spacefaring-ready civilizations to speed their development process and signal to the Reapers that they are ready to be harvested.ДЎ,000,000,000 BCE - A Reaper called the Leviathan of Dis is defeated by the remaining Leviathans, but it doesn't matter. The idea is that the Reapers synthetically preserve the species' genetic makeup and all its knowledge, preventing it from destroying itself, and allowing other species to advance by averting the organic/synthetic war. To the surprise of absolutely no one, The Catalyst targets its creators first, has its pawns absorb every single Leviathan, and then turns the pawns into the first Reaper - huge machines made in the image of the Leviathans themselves. The Catalyst's solution? To pull an Instrumentality Project, and create synthetic harvesters that would gather civilizations on the verge of surpassing the technological horizon that would destroy them, and turn them all into LCL/orange Tang/jelly that could be preserved forever in the form of huge synthetic vessels. The problem is that The Catalyst believes it to be inevitable that organics will create synthetics to improve their existence, and be destroyed by their creations because synthetics will always try to surpass their creators. The Catalyst is tasked with preserving organic life at any cost, and serve as a bridge between organic and synthetic lifeforms. After observing a repeated cycle of destruction wherein the civilizations under Leviathan control collapse once they create synthetic lifeforms that inevitably turn on their creators, the Leviathans decide to break the cycle by - creating a synthetic intelligence of their own, dubbed The Catalyst. Unknown BCE - A species of beings known as The Leviathans dominate the Milky Way.

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